Keywords: COVID-19, Thrombosis, Hemodialysis, Survival analysis Furthermore, AVF thrombosis explained about the 68% of the mortality, evaluated through the Harrel’s C test.Ĭonclusion: We can speculate that AVF thrombosis in hemodialysis patients with COVID-19 could be an early marker of both pro-coagulative process and severe clinical disease and it could be used to stratify patients and identify the ones that can be considered “frail”. Kaplan Meier test showed a death average of 19 days in group B compared to a global average of 38 days (p=0.029), and Cox analysis showed an HR of 5.01, 95% CI 1.01-24.99, p=0.049. Kaplan Meier and Cox regression analysis were performed to compute mortality analysis.
Pearson or Spearman’ correlation tests were performed to detect possible confounding variable to include in multivariate models. Patients were divided based on AVF thrombosis: the A group without AVF thrombosis (13 patients), and the B group with AVF thrombosis events (11 patients). Methods: the analysis included 24 dialysis-dependent patients admitted in a period between March 2020 and June 2021. Our study evaluated the thrombosis of arteriovenous fistula (AVF) as risk marker of mortality. COVID-19-associated coagulopathy is an endothelial disease related to SARS-CoV-2 infection. As a consequence, diagnostic and therapeutic delays have been showed. Vincenzo Calabrese 1, Cristina Micali 2, Ylenia Russotto 2, Natascia Laganà 2, Chiara Gullotta 2, Anna Pisano 3, Domenico Santoro 1, Giuseppe Nunnari 2, Emmanuele Venanzi Rullo 2ġ Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyĢ Unit of Infectious disease, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italyģ CNR-Institute of Clinical Physiology Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italyīackground: Pandemic condition due to Coronavirus disease (COVID-19) caused a fastest augmentation of hospitalization, impairing the healthcare organization.